Two sample MR report
CHD1L_Alveolar Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 13 | 0.0966838 | 0.0723579 | 0.2084716 |
| Weighted median | 13 | -0.0165151 | 0.0073103 | 0.0238743 |
| Inverse variance weighted | 13 | -0.0126510 | 0.0056079 | 0.0240760 |
| Simple mode | 13 | -0.0237020 | 0.0128392 | 0.0896850 |
| Weighted mode | 13 | -0.0231324 | 0.0130393 | 0.1014079 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.015644 | 11 | 0.9304066 |
| Inverse variance weighted | 7.312644 | 12 | 0.8362802 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.069931 | 0.0461413 | 0.1578201 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001628 | 0 | TRUE | 0.2254415 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
